|
週次 |
日期 |
單元主題 |
|
第1週 |
|
Course Introduction: why I should/should not take this course? (為何我要修 (或不修) 這門課?) |
|
第2週 |
|
Milestone 1 (1952) Electophoresis; Milestone 2 (1967, 1972) Discovery of DNA ligase; Cloning The dawn of recombinant DNA |
|
第3週 |
|
Milestone 3 (1969) FISH (fluorescent in situ hybridization); Milestone 4 (1970) Discovery of restriction enzymes |
|
第4週 |
|
Milestone 5 (1970, 1998) Discovery of reverse transcriptase; Full-length cDNA technologies; Milestone 6
(1975) Southern blot |
|
第5週 |
|
Milestone 7 (1977) DNA sequencing; Milestone 8 (1980, 1983) RFLP concept; RFLP realization |
|
第6週 |
|
Milestone 9
(1982, 1987) P-element-mediated manipulation of the fly genome; Site-directed mutagenesis of the mouse genome; Milestone 10 (1982) Whole genome shotgun |
|
第7週 |
|
Milestone 11 (1985) PCR; Milestone 12 (1985) DNA Fingerprinting |
|
第8週 |
|
期中考與期中座談 （或參觀見學) |
|
第9週 |
|
Milestone 13 (1987, 1992) YACs and BACs; Milestone 14
(1988) ChIP |
|
第10週 |
|
Milestone 15 (1990) BLAST — the key to comparative genomics; Milestone 16 (1995) Microarray technology |
|
第11週 |
|
Milestone 17 (1998) RNAi |
|
第12週 |
|
Milestone 18 (1998, 2005) Sequencing by synthesis; Sequencing by ligation/polony sequencing; Milestone 19 (2002) Launch of UCSC Genome Browser |
|
第13週 |
|
Milestone 20 (2003) DNA assembly programs; Milestone 21
(2004) ENSEMBL — an example of a gene annotation tool |
|
第14週 |
|
Milestone 22 (2005) HapMap; Milestone 23 (2006) Genome-wide maps of DNA methylation |
|
第15週 |
|
DNA 科技研究趨勢座談 |
|
第16週 |
|
DNA 科技研究經驗座談 |
|
第17週 |
|
期末考與期末座談 |